Multiple Sclerosis (MS) is a disease with a wide-ranging impact on functional status, often quantified using the Multiple Sclerosis Functional Composite Score (MSFCS). The MSFCS includes the standardized Z-scores of three functional tests: the Paced Auditory Serial Addition Test (PASAT-3”) for cognitive function, 9-Hole Peg Test (9-HPT) for arm function, and timed 25-foot walk (25-TW) for leg function. One of the most common symptoms experienced by MS patients is severe fatigue brought on by aerobic exercise. Non-aerobic maximal effort exercise (MEE) is thought to increase strength without increasing fatigue. The IsoPUMP® (Neuromuscular Engineering; Nashville, TN) is a stationary exercise device designed for patients to safely perform isometric and eccentric MEE leg presses and whole body lunges.